This guide will take approximately 10 minutes to complete.
Advanced search is a precise and powerful tool allowing users to perform a comparative analysis with one click.
In this guide you will:
- Learn how to perform searches with multiple Concepts and compare their results
- Use keywords and filters to refine your search
- Compare the results of each search and look for common and unique relationships
The following guide is also available as a video guide.
To explore the Delta analysis in the Advanced Search Module, common and unique targets for Hypertensive disease, Obesity and Diabetes will be used as an example.
Step 0: Login
Refer to https://med.causaly.com
TIP! In case you forgot your password, you can recover it here.
Step 1: Open the Advanced Search page
Hover over the “Search” tab to access Advanced search. (Figure 1).
Figure 1: Select Advanced search using the highlighted option on the Causaly homepage.
Step 2: Search for Causes of Hypertensive Disease
Type your Concept of interest, in this case, hypertensive disease, in the Concept box on the right. Leave the other Concept box blank to look for all Concepts that affect Hypertensive disease (Figure 2).
Figure 2: Type Hypertensive disease in the Concept box on the right and deselect narrower Concepts to focus your search.
TIP!
- When searching for broad disease indications, deselect narrower Concepts to focus your search. Find out how to choose the most appropriate Concepts for your search here.
- To better understand why we added the disease in the right concept box, you can visit this guide.
Step 3: Add relationship lines to also search for Causes of Obesity and Diabetes
After adding hypertensive disease on the right box of your first line of search, deselect narrower concepts and click on the “add relationship” button (Figure 3).
Figure 3: Click “add relationship” to perform a comparative analysis between two concepts.
Enter “Obesity” and “Diabetes” in the Concept boxes in the added rows. Deselect narrower Concepts as above (Figure 4).
Figure 4: Type “Obesity” and “Diabetes” in the newly added Concept boxes on the right.
Click search.
TIP! You can add up to 10 rows for a single search in order to perform your comparative analysis.
Step 4: Filter for "Causaly Targets" and inspect your results
Results associated with Hypertensive disease, Obesity and Diabetes are displayed in grid view. Use filters on the left to refine your search. Select “Specific Target” under “Causaly Targets”. (Figure 5) (link).
Figure 5: Filter your results for specific targets.
Step 5: Use the network view to visualize the top 100 results
Use the Network view button (top right) to visualize the top 100 results. The three diseases are represented as cores. Explore the targets associated with at least one of the diseases of interest, connected in branches (Figure 6) (link).
Figure 6: Visualize the top 100 results
Step 6: Use the Delta Analysis view to identify common and unique targets
Click the Delta analysis button to find the unique and common targets between Hypertensive disease, Obesity and Diabetes. Results are displayed in an interactive Venn diagram, where each disease is represented by a circle (e.g. Hypertensive Disease - Circle A) (Figure 7) (link).
Figure 7: Delta analysis view for unique and common targets between hypertensive disease, obesity and diabetes
Step 7: Identify Targets unique to Hypertensive Disease
Hover over the different areas of the diagram to see the relevant data. To explore unique targets for hypertensive disease further, click on group A on the diagram.
Step 8: Identify common Targets for Hypertensive Disease, Obesity and Diabetes
To explore the common targets of all three diseases, click on the intersection of the three circles, as indicated in Figure 8.
Figure 8: Select the intersection of the three circles to explore common targets for all three diseases. Your selection details are visible both on the left and right hand sides as marked by the blue boxes.
Step 9: Inspect the relationship between leptin, Hypertensive Disease, Obesity and Diabetes
Click on the leptin relationship to see a breakdown of the evidence for leptin’s relationship with each of the diseases. You can explore these further by clicking on the individual relationships through the sidebar (Figure 9).
Figure 9: Click the leptin relationship to see a breakdown of the number of evidence points linking it to three diseases.
Want to learn more about how to find evidence in Causaly?
Find more information and examples on step-by-step guides here.