This guide will take approximately 5 minutes to complete.
In this guide you will learn how to:
- Explore whether two biomarkers interact with each other
- Refine your search results for a specific disease
- Identify biochemical pathways that are affected by a biomarker of interest in publications referring to a second biomarker in a specific disease context
Step 0: Login
Refer to https://med.causaly.com
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A. Explore direct interactions between two biomarkers of interest in a disease context
Step 1: Use the Intelligent Search to investigate the interaction between two biomarkers of interest.
To initiate your search, use the Intelligent Search on the Causaly home page (Figure 1).
Figure 1. The Intelligent Search on the Causaly homepage
Begin your search by adding a keyword that describes your question into the search box and select the Concept of interest from the suggestions below. To explore the relationship between two biomarkers of interest, add both biomarkers in the input box and select the most relevant from the suggested search topics (Figure 2).
Example: Interaction between BRCA2 and RAD51 (link)
Figure 2: In Intelligent Search, explore the relationship between two biomarkers of interest by typing keywords and selecting the most relevant search topic from the suggestions below.
When you perform a search for the direct interaction between two biomarkers, Causaly will look for associations not only between the two genes of interest, but also for the narrower and related concepts, such as the alleles, variants, mutations etc. (Figure 3).
Figure 3: The causal relationships found between BRCA2 gene and RAD51 gene.
Step 2: Use keywords to refine your results to a specific disease context.
To look for the interaction between two biomarkers in a specific disease context, add on the input box the disease of interest (Figure 4).
Example: Interaction between BRCA2 and RAD51 in breast cancer (link).
Figure 4: Select “Open in advanced search” to refine your query
Results now describe the relationship of BRCA2 with RAD51 in the context of breast cancer (Figure 5).
Figure 5. Explore the results in the Article tab about BRCA2 and RAD51 interaction in breast cancer.
B. Identify biochemical pathways affected by a biomarker in publications referring to a second biomarker for a specific disease.
To explore the pathways affected by a biomarker of interest in a specific disease context, which are also related to a second biomarker, add in your search the keyword pathway(s) and select the most relevant search topic from the suggestions (Figure 6).
Example: Biochemical pathways affected by brca2 in breast cancer in rad51 (link)
Figure 6: Search for the pathways affected by BRCA2 gene in publications referring to RAD51 and breast cancer, by using keywords.