This guide will take approximately 3 minutes to complete.
The purpose of this guide is to walk you through how to explore whether an underlying disease or an indication under evaluation can lead to an adverse event (AE).
Step 0: Log in
Refer to https://med.causaly.com
TIP! In case you’ve forgotten your password, you can recover it here.
Step 1: Explore the direct relationship between an indication and an AE of interest
To investigate the relationship between an IMP and an adverse event, use Causaly Discover in the Causaly home page (Figure 1).
Figure 1. Causaly Discover on the Causaly homepage
Begin your search by typing your question into the Causaly Discover search bar in natural language (Figure 2). “Is vitamin D deficiency associated with multiple sclerosis?” will be used as an example (link).
Figure 2: Directly ask a question in natural language in the Causaly Discover search bar
Click "Search" or hit Enter on your keyboard to run the search, which will direct you to the Causaly Discover results page.
Causaly Discover offers an AI-generated summary, complete with in-line citations for transparency into the results, based on the top 20 articles (Figure 3). You can scroll down to view all the documents retrieved in response to your search query.
Figure 3: The AI- generated summary by Causaly Discover.
Refine your results using filters
Apply filters to refine the results of your search by using the Filters panel just below the AI-generated summary, for example focus on publications from the last 5 years (Figure 4).
Figure 4: Filtering options to refine your search results.
Once you apply filters, the AI-generated summary will be automatically updated to reflect your filter selections.
Click on the “Read in-depth analysis” button to read a more detailed summary of the results or save it in Workspaces by clicking the “Save to Workspaces” button (Figure 5).
Figure 5: Save a summary in Workspaces or click on the “Read in-depth analysis” button to review a longer summary of the results
Step 2: Investigate the epidemiology of an AE in patients with the underlying disease of interest
After establishing a relationship between the AE and disease of interest, such as that between MS and vitamin D deficiency, you can explore the epidemiology of vitamin D deficiency in patients with MS in the Epidemiology module.
Use the Copilot sidebar to ask follow up questions in a conversational manner, using natural language and type “what is the epidemiology of vitamin D deficiency in MS patients?” (Figure 7).
Figure 7: Type your follow up question in natural language in the Copilot sidebar and explore the new AI-generated summary along with the references.
Step 3: Explore the relationship between a concomitant indication and an AE of interest in patients with a specific underlying disease
You can also investigate whether a concomitant disease exacerbates the AE in patients with an underlying disease of interest. For example, you can examine whether diabetes affects vitamin D deficiency in multiple sclerosis patients (link) (Figure 8).
Figure 8: Use Causaly Discover to examine whether a concomitant indication exacerbates the AE in the subpopulation of interest.
Want to learn more about how to find evidence in Causaly?
Find more information and examples on how to search posts by clicking here.