This guide will take approximately 10 minutes to complete.
In this guide you will learn:
- How to search for microRNAs (miRNAs) associated with a disease of interest
- How to find articles relating a specific miRNA with a disease or target of interest
- How to find validated targets for a miRNA of interest
Step 0: Login
Refer to https://med.causaly.com
TIP! In case you forgot your password, you can recover it here.
Search for microRNAs (miRNAs) associated with a disease of interest
To explore all microRNAs associated with a disease of interest, use Causaly Discover in the Causaly home page (Figure 1).
Figure 1: Causaly Discover on the Causaly homepage
Begin your search by typing your question into the Causaly Discover search bar in natural language (Figure 2). “What microRNAs are associated with CLL?” will be used as an example (link).
Figure 2: Directly ask a question in natural language in the Causaly Discover search bar
Click "Search" or hit Enter on your keyboard to run the search, which will direct you to the Causaly Discover results page.
Causaly Discover offers an AI-generated summary, complete with in-line citations for transparency into the results, based on the top 20 articles. You can scroll down to view all the documents retrieved in response to your search query.
In addition, Causaly Discover will prompt you to visit the Bio Graph to review the miRNAs in a dendrogram list and be able to deep dive into their unique relationships with the disease of interest. Click on View analysis to open the Causaly Bio Graph knowledge card (Figure 3).
Figure 3: Causaly Bio Graph card linking your search query to Causaly dendrogram results.
TIP! If you are used to working with keywords on Intelligent Search and/or would like to review the results directly in the Causaly Biograph, you can select the option to return to your previous Causaly experience and initiate your search there by clicking the “Intelligent Search” option under “Biograph” on top of your Causaly homepage (Figure 4).
Figure 4: Access the previous Causaly interface, by clicking on Biograph and selecting the “Intelligent Search” option
Look for a specific miRNA related to a disease of interest
To explore the relationship between a miRNA and a disease of interest, you can add the names in the Causaly Discover Search bar. The example used below is for MIR15A and CLL (link) (Figure 5).
Figure 5: Explore the relationship between MIR15A and CLL.
On the search page, you will find a structured AI-generated summary that reviews the top evidence, providing an overview of the search topic supported by in-line, linked citations for transparency and traceability.
The Causaly Biograph option will not be available for searches looking at direct associations (eg., miRNA and CLL). You can still review the supporting documents though by scrolling down to the results page; just below the AI-generated summary.
Look for targets related to a specific miRNA
To explore the potential targets of a miRNA of interest, ask your question in natural language in the Causaly Discover Search bar, such as the example indicated below (link) (Figure 6).
Figure 6: Directly ask a question in natural language in the Causaly Discover search bar
The AI-generated summary will be displayed on top of your results page, supported by the documents below, as well as the Causaly Biograph card, which will provide you with a comprehensive list of targets in a dendrogram view.
Find validated targets for a miRNA of interest
To ask a follow up question and look for validated targets for a miRNA of interest, by a specific assay (e.g. luciferase) or a specific function (e.g. loss-of function, gain of function, silencing etc.) use the input box at the bottom right corner of your screen, below the Causaly Biograph card (Figure 7).
Figure 7: The input box at the bottom right corner of your screen to ask follow up questions.
In this way the results will be based on studies where the different targets of MIR16-1 have been validated using luciferase reporter assays.
Want to learn more about how to find evidence in Causaly?
Find more information and examples on how to search posts by clicking here.