This guide will take approximately 5 minutes to complete.
The purpose of this guide is to help you identify biomarkers associated with treatment response or the course of a disease of interest.
You will learn how to locate:
- Biomarkers associated with response to treatment X
- Biomarkers to monitor the course of disease Y
Step 0: Login
Refer to https://med.causaly.com
TIP! In case you’ve forgotten your password, you can recover it here.
A. Identify biomarkers associated with response to treatment X
Step 1. Use the Intelligent Search to look for biomarkers used to monitor response to treatment X
Use the Intelligent Search in the Causaly homepage (Figure 1).
Figure 1. The Intelligent Search in the Causaly homepage
Begin your search by adding the treatment of interest in the input box and selecting the most relevant Concept from the suggestions below. To explore biomarkers used to monitor treatment response, add the necessary search terms (i.e. biomarkers, response, treatment response) in the input box and select the most relevant search topic from the suggestions below (Figure 2).
Example: Biomarkers of treatment response for anti-PD1 therapy (link)
Figure 2. In Intelligent Search, explore the biomarkers of treatment response by typing keywords and selecting the most relevant search topic from the suggestions below.
TIP! As you type, the system suggests relevant Concepts below with the associated amount of evidence on the right. Based on your research objectives, you can select the Concept most relevant to your search.
Browse your results and investigate the different biomarkers used to monitor treatment response to anti-PD1 therapy presented in an interactive dendrogram view (Figure 3).
Figure 3. Interactive dendrogram view of biomarkers of treatment response to anti-PD1 therapy
Step 2. Focus on biomarkers of treatment response for therapy X in a disease population of interest
To find biomarkers of treatment response of therapy X in a subpopulation of interest, use additional keywords in the input box. The proposed search topics will now change depending on the new keyword and you can explore the results by clicking on the search topic of interest.
Example: Biomarkers of treatment response for anti-PD1 therapy in lung cancer patients (link) (Figure 4)
Figure 4. To identify biomarkers of treatment response for anti-PD1 therapy in a patient subpopulation add keywords in the input box and select the appropriate search topic from the suggestions below
TIP! Clicking on a biomarker of interest in the dendrogram view will reveal a sidebar with the supporting evidence for that relationship. You can further explore the evidence by clicking on the “Inspect” button at the top of this sidebar.
B. Identify biomarkers associated with the course of disease Y
With Intelligent Search, you can explore and identify biomarkers associated with the course of a disease of interest, including biomarkers of disease progression or survival. Similar to Approach A, add your keywords in the input box and select the most relevant search topic from the suggestions below (Figure 5).
Figure 5. In Intelligent Search, explore the biomarkers options, such as biomarkers of disease progression, by typing keywords and selecting the most relevant search topic from the suggestions below.
Results are displayed in an interactive dendrogram view (Figure 6).
Figure 6: The dendrogram view when looking for biomarkers of disease progression in breast cancer patients
TIP!
- You can navigate to the ‘Articles’ tab to explore all the supporting evidence.
Click on the “Save” button to save your search and create alerts to receive notifications when new data regarding a relationship of interest becomes available (Figure 7).
Figure 7. Click on the “Save” button to save your searches