This guide will take approximately 5 minutes to complete.
The purpose of this guide is to help you identify the targets in a specific disease setting.
In this guide you will learn how to locate:
- All targets for disease X studied in biomedical literature
- The targets for disease X in clinical studies
- The targets for disease X in pre-clinical studies
Step 0: Login
Refer to https://med.causaly.com
TIP! In case you’ve forgotten your password, you can recover it here.
A. All targets for disease X
Step 1. Use the Intelligent Search to look for targets related to disease X
To explore the targets for a specific indication, use the Intelligent Search on the Causaly homepage (Figure 1).
Figure 1. The Intelligent Search on the Causaly homepage
By using the Intelligent search, you can find targets for disease X by typing the relevant keywords in the text box.
Example: Targets of CLL (link) (Figure 2)
Figure 2: The proposed suggestions when looking for targets of CLL
TIP! You can use this input box to search for keywords that describe your question. For more information on how to properly use it, you can visit this guide.
After selecting the “Targets of CLL” option, as illustrated in Figure 2, the system will automatically initiate the search by using the filter "Causaly targets" by default.
Step 2: Review the targets
By reviewing the filter on the left, you can see that there are multiple categories classified as specific or generic targets. Based on what you consider a target, you may want to add one or more of the other UMLS filters, and/or remove some of the selected ones.
Results are displayed in an interactive dendrogram view (Figure 3).
Figure 4: The dendrogram view when looking for the targets of CLL
TIP!
- You can either navigate to the ‘Articles’ tab to explore all the supporting evidence, or select the ‘Relationships’ tab to view all the relationships and investigate only those that are of interest.
- Clicking on a target of interest in the dendrogram view will reveal a sidebar with the supporting evidence for that relationship. You can further explore the evidence by clicking on the “Inspect” button at the top of this sidebar.
B. Targets for disease X in clinical studies
After finding all the targets for the disease following the steps above, you can refine the targets only to those coming from clinical studies by using the filters on the left. You can select:
- The Data Source filter: ClinicalTrials.gov to review all targets that have been examined in Clinical Trials published on the registry of the United States National Library of Medicine (NLM). OR
- The publication type filter: Clinical Trial (and Randomized Clinical Trial and/or Controlled Clinical Trial) to find targets in studies predicted to contain clinical information from various data sources. For more information on this filter click here.
- An additional keyword in the input box: By adding "clinical studies" or "clinical data" or "clinical trials" on the input box of the Intelligent Search bar, Causaly will refine for the relevant data.
Example: Targets of CLL in clinical trial studies (link) (Figure 4).
Figure 4: Relevant articles when looking for targets of CLL in clinical trial studies
C. Targets for disease X in pre-clinical studies
After finding all the targets for the disease you can refine the targets only to those coming from from preclinical studies, following the options below:
- Use the species filter: If you are interested in animal studies, you can directly select each of the species on the left to review the relevant literature.
- Refine with the text box: If you are interested in other species, or in vitro data or all pre-clinical studies, use the input box to refine your search by using the keywords of your choice (Figure 5).
Figure 5: Refine the search to the species of interest
In the dendrogram view, you can explore all targets for a disease of interest examined in pre-clinical studies or specific animal species.
Want to learn more about how to find evidence in Causaly?
Find more information and examples on how to search posts by clicking here.