This guide will take approximately 5 minutes to complete.
In this guide you will learn:
- How to find targets for disease X
- How to refine your results to focus on preclinical or clinical studies
Step 0: Login
Refer to https://med.causaly.com
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A. Targets for disease X
Step 1. Use Causaly Discover to look for targets related to disease X
To explore the targets for a specific indication, use Discover on the Causaly homepage (Figure 1).
Figure 1. Discover on the Causaly homepage
Begin your search by typing your question into the Causaly Discover search bar in natural language (Figure 2). “What are the targets of CLL?” will be used as an example (link).
Figure 2: Ask your question in natural language in the Causaly Discover search bar
Causaly Discover offers an AI-generated summary, complete with in-line citations for transparency into the results, based on the top 20 articles. You can scroll down to view all the documents retrieved in response to your search query.
In addition, Causaly Discover will prompt you to visit the Bio Graph to review the side effects in a dendrogram list and be able to deep dive into their unique relationships with the drug of interest. Click on the Causaly Bio Graph knowledge card to explore the comprehensive list of results (Figure 3).
Figure 3: Causaly Bio Graph knowledge card provides results in a dendrogram
Step 2: Refine results to focus on targets in preclinical studies
To refine the results to a specific disorder, you can ask a follow-up question in Causaly Copilot. Remember Causaly Copilot is conversational so you don’t have to type your initial question again. In the below example, we are looking for targets of CLL in preclinical studies by simply writing “In Preclinical Studies” in the Causaly Copilot window on the right (Figure 4). The system will understand you are looking for side effects of the drug in the specified disease. Causaly Copilot will provide you with an updated AI-generated summary of your updated results.
Figure 4: Refine results by asking a follow-up question in Causaly Copilot window
Step 3: Refine results to focus on targets in clinical studies
You can also use Causaly filters to refine your results. If you are interested in looking at "Targets for CLL in Clinial Studies", you can apply Data Source > clinicaltrials.gov filter. You can also filter by publication type to select for publications on clinical trial data, randomized controlled trial etc.
Figure 5: Refine results by selecting one or more Causaly filters
Want to learn more about how to find evidence in Causaly?
Find more information and examples on how to search posts by clicking here.