This guide will take approximately 5 minutes to complete.
The purpose of this guide is to help you identify targets that commonly affect a disease and a biological process of interest.
Step 0: Login
Refer to https://med.causaly.com
TIP! In case you’ve forgotten your password, you can recover it here.
Step 1. Open the Advanced Search Module
To explore the targets that commonly affect a specific indication and a biological process, access the Advanced search module by hovering over the search tab (Figure 1).
Figure 1. Access the Advanced Search module by hovering over the search tab at the top of the page
Step 2: Search for common causes of the disease and the process of interest
Type one Concept of interest in the Concept box on the right and leave the other Concept box blank to look for all Concepts that affect it. Then, click on the “+Add relationship” button to insert an extra search line and look for Concepts that affect the other concept of interest at the same time.
Example: Which targets affect atopic dermatitis and are related to mast cell activation? (link)(Figure 2)
Figure 2: Click “add relationship” at the bottom left corner to add rows. Type the other concept of interest in the newly added concept box.
TIP!
- Add up to 10 different lines by using the Advanced search module. For more information on how the comparative analysis works, click here.
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When searching for broad disease indications, deselect narrower Concepts to focus your search. Find out how to choose the most appropriate Concepts for your search here.
Step 3: Filter for "Amino acid, Peptide or Protein" and "Gene or Genome" and inspect your results
Results associated with either the disease or the biological process of interest are displayed in the articles tab. Use filters on the left to refine your search. Select “Amino acid, Peptide or Protein” under “Chemicals and Drugs” and “Gene or Genome” under “Genes & Molecular sequences”. (Figure 3)
Figure 3: Filter your results for genes and proteins to limit to targets.
Step 4: Identify common targets in the Delta Analysis view
To explore the common targets for the disease and the biological process of interest, select the “Delta Analysis” view and click on the intersection of the two circles, as indicated in Figure 4.
Figure 4: Example: Targets that commonly affect Atopic dermatitis and mast cell activation (link). Select the intersection of the two circles to explore the targets that commonly affect the two. Your selection details are visible both on the left and right hand sides as marked by the blue boxes. On the results list you can see a grid view with the top 100 of 520 common targets.
TIP!
- To further explore a relationship between a gene and the disease and/or process of interest, click on the individual relationships through the sidebar.
- To investigate the targets that are unique for the disease or the biological process, click on the A or B area, respectively.
Want to learn more about how to find evidence in Causaly?
Find more information and examples on how to search posts by clicking here.